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Check Carefully (1)pentobarbital will reduce the extent or result of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers could lead into a lessen in fentanyl plasma concentrations, deficiency of efficacy or, possibly, development of the withdrawa